刘如川

 

研究方向：

3D生物打印和物理在生物医学中的应用，纳米/分子器件与太阳能电池材料，细胞内信号传输过程及蛋白质间的相互作用，及相关的计算机理论计算和分子动力学模拟。

学习与工作经历：

2012年至今百人计划特聘研究员，博导，重庆大学物理学院

2013年至今客座副教授，新加坡国立大学物理系

2009-2012年PI研究员，新加坡机械生物研究所

2007-2012年助理教授，新加坡国立大学物理系

2005-2007年博士后研究员，美国哥伦比亚大学生物系

2004-2005年博士后研究员，美国太平洋西北国家实验室基础科学部

1999-2004年博士，物理化学，哥伦比亚大学，美国纽约

1994-1999年博士，凝聚态物理，中国科学技术大学，中国安徽合肥

1990-1994年学士，材料物理，中国科学技术大学（郭沫若奖），中国安徽合肥

主要科研项目：

  1. 重庆市基础与前沿研究项目，2018－

  2. 重庆市基础与前沿研究项目，2013－2016

  3. 重庆大学百人计划启动项目，2013－

  4. The Elasticity and Homophilic Interactions of Extracellular Domain of Cadherins -- A Study by Single-Molecule Experiments，新加坡机械生物研究所项目，2009－2012

  5. From Bio Mimicking to Ultra and Multi Functional Bio Composite Materials，新加坡国立大学科学学院种子项目，2010

  6. Single-Molecule Fluorescence / Force Spectroscopy of Green Fluorescent Protein，新加坡国立大学Tier 1项目，2008－2011

  7. Single-Molecule Force Spectroscopy of Interaction between Calmodulin and Peptids, 新加坡国立大学启动基金，2007－2009

  8. Micromechanics of the Extracellular Matrix，美国卫生研究院项目

  9. Molecular Basis of Titin Elasticity，美国卫生研究院项目

  10. 美国能源部太平洋西北国家实验室项目，研究钙调蛋白的信号发生过程和光收集结合体光电信号传输中的动力学过程

  11. 美国能源部、美国自然科学基金材料中心和美国自然科学基金纳米中心项目，研究分子和纳米复合材料中的电荷转移

  12. 中国国家自然科学基金项目，碳化硅薄膜的生长研究

学术论文：

已发表SCI索引期刊论文40多篇，被引用近1700次。

  1. "Multifunctional atomic force probes for Mn2+ doped perovskite solar cells", Y. Wu, W. Chen, Z. Wan, A. Djurisic, X. Feng, L. Liu, G. Chen, R. Liu, Z. He, Journal of Power Sources 425(2019) 130-137 (通讯作者)
  2. "General Method To Define the Type of Carrier Transport Materials for Perovskite Solar Cells via Kelvin Probes Microscopy", Y. Wu, W. Chen, Y. Lin, B. Tu, Z. Wu, R. Liu, L. Liu, A. Djurišić, Z. He,  ACS Appl. Energy Mater. 1, 3984-3991 (2018) (通讯作者)
  3. "Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy", H. Xie, Y. Jiao, Q. Fan, M. Hai, J. Yang, Z. Hu, Y. Yang, J. Shuai, G. Chen, R. Liu, L. Liu, Plos One 13(10): e0206292 (2018) (通讯作者)
  4. "The Impact of Hybrid Compositional Film/Structure on Organic-Inorganic Perovskite Solar Cells”, Y. Wu, W. Chen, G. Chen, L. Liu, Z. He, R. Liu, Nanomaterials 8 (6) doi: 10.3390/nano8060356 (2018) (通讯作者)
  5. "Realizations of highly heterogeneous collagen networks via stochastic reconstruction for micromechanical analysis of tumor cell invasion", H. Nan, L. Liang, G. Chen, L. Liu, R. Liu, Y.  Jiao, Physical Review E 97 (3) 033311 (2018) (通讯作者)
  6. "Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases", K. Song, Z. Wang, R. Liu, G. Chen, L. Liu, International Journal of Molecular Science 19 (4) doi:10.3390/ijms19040935 (2018)
  7. "SKPM study on organic-inorganic perovskite materials", K. Song, Y. Wu, X. Chen, Y. He, L. Liu, G. Chen, R. Liu, AIP Advances 8 (3) 0351114 (2018) (通讯作者)
  8. "Enhancing the performance of NaNbO3 triboelectric nanogenerators by dielectric modulation and electronegative modification", M. Lai, L. Cheng, Y. Xi, Y. Wu, C. Hu, H. Guo, B. Du, G. Liu, Q. Liu, R. Liu, J. Phys. D: Appl. Phys. 51 (2018) 015303 (10pp) (2017) (通讯作者)
  9. "Derivation of persistent time for anisotropic migration of cells", Y. Liu, X. Zhang, Y. Wu, W. Liu, X. Li, R. Liu, L. Liu, J. Shuai, Chin. Phys. B Vol. 26, No. 12 (2017) 128707 (2017)
  10. "A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructure reveals complex tumourstroma interactions", Q. Fan, R. Liu, Y. Jiao, C. Tian, James D. Farrell, X. Wang, F. Zhang, W. Yuan, H. Han, J. Chen, Y Yang, X. Zhang, F. Ye, M. Li, Z. Ouyang, and L. Liu, Lab on a Chip DOI:10.1039/C7LC00191F (2017)
  11. "‘Nano Fishnet’ Structure Making Silk Fibers Tougher", R. Liu, Q. Deng, Z. Yang, D. Yang, M. Han and X. Liu, Adv. Func. Mater. doi: 10.1002/adfm.201600813 (2016) (通讯作者)
  12. "Oriented Collagen Fibers Direct Tumor Cell Intravasation", W. Han, S. Chen, W.Yuan, Q. Fan, J. Tian, X. Wang, L. Chen, X. Zhang, W. Wei, R. Liu, J. Qu, Y. Jiao, R. H. Austin, L. Liu, Proc. Natl. Acad. Sci. USA(2016)
  13. "In vitro experimental models and their molding technology of tumor cell", G. Wang, X. Wang, T. Liu, R. Liu, L. Liu, Acta Phys. Sin. 65(18) 188700 (2016) (通讯作者)
  14. "Single molecule fluorescence spectroscopy for quantitative biological applications", R. Liu, Y. Li, L. Liu, Quantitative Biology 4(3): 177-191 (2016)
  15. "Charges on nano-islands and fibrils of poly(3-hexylthiophene-2,5-diyl) – light-modulation, injection and transportation", H. Xuan, X. Chen, Y. Wu, K. Song, Y. Li and R. Liu,RSC Adv., 6, 15577 (2016) (通讯作者)
  16. "Uncovering mechanosensing mechanisms at the single protein level using magnetic tweezers", S. Le, R. Liu, C. T. Lim, and J. Yan, Methods 94, 13 (2016)
  17. "Homophilic Interaction and Deformation of E-cadherin and Cadherin 7 Probed by Single Molecule Force Spectroscopy", F. Wu, C. Lu, J.P. Thiery, C.T. Lim, S. Shen, S. Zhong and R. Liu, Archives of Biochemistry and Biophysics, 587, 38 (2015) (通讯作者)
  18. "Hybrid nanogenerators based on triboelectrification of a dielectric composite made of lead-free ZnSnO3 nanocubes", G. Wang, Y. Xi, H. Xuan, C. Hu, R. Liu, X. Chen, L. Cheng, Nano Energy 18, 28 (2015)（通讯作者）
  19. "Unique synthesis of sandwiched graphene@(Li0.893Fe0.036)Co(PO4) nanoparticles as high-performance cathode materials for lithiumion batteries", L. Liu, H. Zhang, X. Chen, L. Fang, Y. Bai, R. Liu and Y. Wang, J. Mater. Chem. A, 3, 12320, (2015)
  20. "Plasmon-driven surface catalysis in hybridized plasmonic gap modes", H. Wang, T. Liu, Y. Huang, R. Liu, X. Wang, W. Wen, M. Sun, Scientific Reports, 4, (2014)
  21. "Force-dependent conformational switch ofa-catenin controls vinculin binding", M. Yao, W. Qiu, R. Liu, A. K. Efremov, P. Cong, R. Seddiki, M. Payre, C. T. Lim, B. Ladoux, R. Mège, J. Yan, Nature Communications, 5, 4525 (2014)
  22. "Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain - Implication in Mechanosensing", K. Hotta, S. Ranganathan, R. Liu, F. Wu, H. Machiyama, R. Gao, M. M. Kanchi, K. Ohe, C.-Y. Kim, Y. Sawada, PLOS Computational Biology, 10, e1003532 (2014) doi:10.1371/journal.pcbi.1003532
  23. "Hybrid Organic/Inorganic Nanocomposites for Photovoltaic Cells", R. Liu, Materials, 7, 2747 (2014) doi:10.3390/ma7042747
  24. "P130Cas Substrate Domain is Intrinsically Disordered as Characterized by Single-Molecule Force Measurements", C. Lu, F. Wu, W. Qiu, and R. Liu, Biophysical Chemistry, 180, 37-43 (2013)（通讯作者）
  25. "Bipedal Nanowalker by Pure Physical Mechanisms", J. Cheng, S. Sreelatha, R. Hou, A. Efremov, R. Liu, J. RC van der Maarel, Z. Wang, Phys. Rev. Lett., 109, 238104 (2012)
  26. "Remarkable Disparity in Mechanical Response among Extracellular Domains of Type I and II Cadherins", R. Liu, F. Wu, J.P. Thiery, Journal of Biomolecular Structures and Dynamics, 31, 1137 (2013) (通讯作者)
  27. "Stretching Single Talin Rod Molecules Activates Vinculin Binding", A. del Rio, R. Perez-Jimenez, R. Liu, P. Roca-Cusachs, J. M. Fernandez and M. P. Sheetz, Science 323, 638-641 (2009)
  28. "Mechanical characterization of Protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry", R. Liu, S. Garcia-Manyes, A. Sarkar, C. L. Badilla and J. M. Fernandez, Biophysical Journal 96(9), 3810-3821 (2009) (通讯作者)
  29. "Imaging of photoinduced interfacial charge separation in conjugated polymer/ semiconductor nanocomposites", R. Liu, J. Phys. Chem. C 113 (21), 9368-9374 (2009) (通讯作者)
  30. "Fluctuating Two-State Light Harvesting in a Photosynthetic Membrane", D. Pan, D. Hu, R. Liu, X. Zeng, S. Kaplan, H. P. Lu, J. Phys. Chem. C 111 (25), 8948-8956 (2007)
  31. "Revealing Two-State Protein-Protein Interactions of Calmodulin by Single-Molecule Spectroscopy", R. Liu, D. Hu, X. Tan, H. P. Lu, J. Am. Chem. Soc.128(31), 10034-10042 (2006)
  32. "A Conformational Switch of Intramolecular Electron Transfer", M. W. Holman, P. Yan, K.-C. Ching, R. Liu, F. I. Ishak, D. M. Adams. Chem. Phys. Lett. 413(4-6), 501-505, (2005)
  33. "Studying and Switching Electron Transfer: From the Ensemble to the Single Molecule", M.W. Holman, R. Liu,L. Zang, P. Yan, S.A. Dibenedetto, R.D. Bowers, D. M. Adams, J. Am. Chem. Soc. 126(49), 16126-16133 (2004)
  34. "Single-Molecule Spectroscopy of Interfacial Electron Transfer", M.W. Holman, R. Liu, D.M. Adams, J. Am. Chem. Soc. 125(41), 12649-54, (2003).
  35. "Single-Molecule Spectroscopy of Intramolecular Electron Transfer in Donor-Bridge-Acceptor Systems", R. Liu, M.W. Holman, L. Zang, D.M. Adams, J. Phys. Chem. A 107(34), 6522-6526, (2003).
  36. "A Single-Molecule Probe Based on Intramolecular Electron Transfer", L. Zang, R. Liu, M.W. Holman, K. T. Nguyen, D.M. Adams, J. Am. Chem. Soc.124(36), 10640-10641 (2002).
  37. "Edge Transfer Lithography of Molecular and Nanoparticle Materials", O. Cherniavskaya, A. Adzic, C. Knutson, B.J. Gross, L. Zang, R. Liu, D.M. Adams, Langmuir 18(18), 7029-7034, (2002).
  38. "Ultraviolet photoluminescence from 4H-SiC nanocrystalline films deposited on silicon substrate", Z. Fu, B. Yang, R. Liu, Y. Ruan, J. Mat. Res. 17(3), 570-574, (2002).
  39. "Intense ultraviolet photoluminescence from amorphous Si:O:C films prepared by liquid-solution-phase technique", Z. Fu, M. Li, B. Yang, R. Liu, Thin Solid Films 389(1,2), 12-15, (2001).
  40. "alpha-SiC layers grown on silicon via nano-sized silicon nitride precursor route", R. Liu, B. Yang, Z. Fu, Q. Chen, L. Hong, M. Li, Z. Liu, Y. Ruan, Thin Solid Films 345(2), 188-191, (1999).
  41. "Intense green-yellow luminescence from nanostructured SiO2 with codoping of Dy3+ and Al3+", Y. Li, C. Mo, L. Zhang, R. Liu, Y. Liu,Nanostructured Materials 11(3), 307-310, (1999).
  42. "New method to grow preferentially-oriented 4H-SiC films on Si substrate", Z. Fu, B. Yang, R. Liu, P., Zhang, Y. Ruan, Chinese Science Bulletin 44(6), 575-576, (1999).
  43. "Preparation of a SiOxCyHz ultraviolet-emitting films by benzene-thermal synthesis method", M. Li, Z. Fu, B. Yang, H. Chen, R. Liu, Y. Ruan, Zhongguo Kexue Jishu Daxue Xuebao 29(6), 730-734, (1999).
  44. "SiC films grown on silicon by pyrolysis of polyimide Langmuir-Blodgett films containing dispersed silicon nanoparticles", Z. Fu, B. Yang,R. Liu, J. Fu, P. He, Z. Liu, Y. Ruan, Mat. Lett. 37(4-5), 294-297, (1998).
  45. "Stable blue-green and ultraviolet photoluminescence from silicon carbide on porous silicon", R. Liu, B. Yang, Z. Fu, P. He, Y. Ruan, Solid State Comm. 106(4), 211-214, (1998).
  46. "Intense green luminescence associated with two-fold coordinated Si in silica aerogel doped with Al3+", Y. Li, C. Mo, L. Yao, R. Liu, W. Cai, X. Li, Z. Wu, L. Zhang, J. Phys: Condensed. Matter 10(7), 1655-1664, (1998).
  47. "不同退火条件对（Hg，Tl）-1223热电势率的影响"，张辉，许勤伦，杨碚芳，付正平，刘如川，李明，阮耀钟，低温物理学报20(3)，169-173，(1998)

  • 授权发明专利：重庆大学，刘如川，光激活单分子荧光生物化学反应动力学显微镜及试验方法，2013102365072，2013年，中国

    学生培养：

    2013－2014指导本科生国创项目《微射流的反射与折射及调控》

    2013－2014指导本科生物理竞赛，获得重庆大学第一

    友情链接：

    ·Professor Julio Fernandez    Columbia University, USA

    ·Professor Louis Brus            Columbia University, USA

    ·Professor Peter Lu               Bowling Green State University, USA

    ·Professor Ling Zang            The University of Utah, USA

    Chongqing University

    Biomedical Physics Laboratory

     

    Institute of Physics CAS

    Microfluidic Biophysics Laboratory

    ©2016-2019

    CONTACT INFORMATION

    Address: Chongqing University, Huxi Campus, College Town, Shapingba District, Chongqing, P. R. China

    Zip: 401331

    Telephone: +86-023-65678391